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KMID : 1161420130160070669
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Journal of Medicinal Food
2013 Volume.16 No. 7 p.669 ~ p.671
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Enhancement of the Antifungal Activity of Antimicrobial Drugs by Eugenia uniflora L.
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Santos Karla K. A.
Matias Edinardo F. F.
Tintino Saulo R.
Souza Celestina E. S.
Souza Celestina E. S.
Guedes Glaucia M. M.
Costa Jose G. M.
Menezes Irwin R. A.
Coutinho Henrique Douglas Melo
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Abstract
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Candidiasis is the most frequent infection by opportunistic fungi such as Candida albicans, Candida tropicalis, and Candida krusei. Ethanol extract from Eugenia uniflora was assayed, for its antifungal activity, either alone or combined with four selected chemotherapeutic antimicrobial agents, including anphotericin B, mebendazole, nistatin, and metronidazole against these strains. The obtained results indicated that the association of the extract of E. uniflora to metronidazole showed a potential antifungal activity against C. tropicalis. However, no synergistic activity against the other strains was observed, as observed when the extract was associated with the other, not enhancing their antifungal activity.
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KEYWORD
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antifungal activity, Candida sp., citotoxicity, Eugenia uniflora, modifying activity
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